Patients with SBS who are dependent on PS are at an increased risk of disabling
and life-threatening
complications1

Patients with SBS live with
debilitating physical burdens
OF THEIR CONDITION2-4

  • Abdominal pain
  • Frequent bowel movements
  • Stool incontinence
  • Decreased energy levels

I find emotional well-being in good days when I can leave the house, engage in activities, and maintain an active lifestyle, which brings me joy amidst the challenges.

- Carol, living with SBS and dependent on PS

Despite these burdens, many patients exhibit resilience and adaptability with their new routines and lifestyles5

SBS and PS can lead to dangerous clinical complications

SBS may put patients at an increased risk for4,6,7

  • Small bowel bacterial overgrowth
  • Hypotension
  • Sepsis
  • Renal impairment
  • Metabolic bone disease
  • Fatty acid deficiency

Patients with SBS who are dependent on PS face a HEIGHTENED probability of mortality8

Patients with SBS represent a heterogeneous population, with age, medical history, duration of PS, and care team contributing to overall
prognosis and mortality rate.6
1 IN 3 PATIENTS won’t survive the first 5
years after diagnosis6
HIGHER RATE
OF MORTALITY compared to the general
population8,9

Due to the physical challenges and heterogeneity of SBS, it’s important to establish an individualized approach depending on each patient’s needs2,10

PS=parenteral support; SBS=short bowel syndrome.
REFERENCES

1. Ballinger R, Macey J, Lloyd A, et al. Measurement of utilities associated with parenteral support requirement in patients with short bowel syndrome and intestinal failure. Clin Ther. 2018;40(11):1878-1893.e1. doi:10.1016/j.clinthera.2018.09.009

2. Data on file. SBS patient insights program: digital ethnography study report. Trinity, LLC. August 16, 2023.

3. Jeppesen PB, Pertkiewicz M, Forbes A, et al. Quality of life in patients with short bowel syndrome treated with the new glucagon-like peptide-2 analogue teduglutide—analyses from a randomised, placebo-controlled study. Clin Nutr. 2013;32(5):713-721. doi:10.1016/j.clnu.2013.03.016

4. Jeppesen PB. Spectrum of short bowel syndrome in adults: intestinal insufficiency to intestinal failure. JPEN J Parenter Enteral Nutr. 2014;38(suppl 1):8S-13S. doi:10.1177/0148607114520994

5. Winkler MF, Smith CE. Clinical, social, and economic impacts of home parenteral nutrition dependence in short bowel syndrome. JPEN J Parenter Enteral Nutr. 2014;38(suppl 1):32S-37S. doi:10.1177/0148607113517717

6. Parrish CR, DiBaise JK. Managing the adult patient with short bowel syndrome. Gastroenterol Hepatol (NY). 2017;13(10):600-608.

7. Pironi L, Arends J, Baxter J, et al. ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults. Clin Nutr. 2015;34(2):171-180. doi:10.1016/j.clnu.2014.08.017

8. Schalamon J, Mayr JM, Höllwarth ME. Mortality and economics in short bowel syndrome. Best Pract Res Clin Gastroenterol. 2003;17(6):931-942. doi:10.1016/s1521-6918(03)00079-9

9. Fuglsang KA, Brandt CF, Jeppesen PB. Survival in patients initiating home parenteral support due to nonmalignant short bowel syndrome compared with background population. Clin Nutr ESPEN. 2022;50:170-177. doi:10.1016/j.clnesp.2022.05.023

10. Bielawska B, Allard JP. Parenteral nutrition and intestinal failure. Nutrients. 2017;9(5):466. 2017. doi:10.3390/nu9050466

11. Low blood pressure (hypotension). Mayo Clinic. Accessed June 7, 2024. https://www.mayoclinic.org/diseases-conditions/low-blood-pressure/symptoms-causes/syc-20355465

12. Septicemia. Johns Hopkins Medicine. Accessed April 11, 2024. https://hopkinsmedicine.org/health/conditions-and-diseases/septicemia

13. Essential fatty acid deficiency. Parrish CR, ed. In: Nutrition Issues in Gastroenterology, Series #164. Published June 2017. Accessed May 14, 2024. https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2014/06/Parrish-June-17.pdf